The European flounder is used for human consumption but is not so highly esteemed as the European plaice or common sole (Solea solea). The most important fisheries are in the Baltic Sea and the waters around the Netherlands and Denmark. In 2010, the total world catch was about nineteen thousand tonnes, mostly caught by bottom trawling. The fish is marketed fresh and frozen and can be fried, boiled, steamed, baked or microwaved.
It has been found that male European flounders living in polluted estuaries may show signs of excess exposure to oestrogens. Substances such as vitellogenins have been identified in their blood at between four and six times the concentration found in the blood of fish from uncontaminated areas; however, the flounder is less sensitive to oestrogens than is the freshwater rainbow trout.